If you’re exploring options for weight loss medication, you’ve likely come across Mounjaro (tirzepatide) and Wegovy (semaglutide). Both are weekly injections that help with appetite control and weight management. But what exactly are the differences between Mounjaro and Wegovy, and which one works better for weight loss?
In this guide, we’ll break down how each medication works, their effectiveness, side effects, and key comparisons to help you understand which option may be right for you.
What Is Mounjaro?
Mounjaro is an injectable medication containing tirzepatide, originally developed for type 2 diabetes. It works by mimicking two natural gut hormones:
- GLP-1: reduces hunger, slows digestion, and helps you feel full.
- GIP: supports blood sugar control and boosts the effects of GLP-1.
Because of this dual action, Mounjaro not only helps with blood sugar regulation but also leads to significant weight loss, especially when combined with a healthy diet and exercise.
What Is Wegovy?
Wegovy contains semaglutide, a GLP-1 receptor agonist. It was specifically designed for weight loss and long-term weight management, especially in people with overweight or obesity who also have weight-related health conditions like high blood pressure or type 2 diabetes.
Like Mounjaro, Wegovy works best when paired with lifestyle changes such as diet and exercise.
Mounjaro vs Wegovy: Which Works Better for Weight Loss?
When it comes to Mounjaro vs Wegovy weight loss results, studies suggest Mounjaro may have the upper hand.
- Mounjaro (tirzepatide): Up to 20.2% weight loss after 72 weeks at maximum dose.
- Wegovy (semaglutide): Around 13.7% weight loss over the same time period.
In short, Mounjaro appears more effective overall, thanks to its dual action on GLP-1 and GIP. However, some people may see faster early results with Wegovy.
Key Differences Between Mounjaro and Wegovy
| Feature | Mounjaro (tirzepatide) | Wegovy (semaglutide) |
|---|---|---|
| Type of drug | GLP-1 & GIP receptor agonist | GLP-1 receptor agonist |
| Primary use | Type 2 diabetes & weight loss | Weight loss only |
| Dosing frequency | Weekly injection | Weekly injection |
| Max dose | 15 mg | 2.4 mg |
| Injection sites | Stomach, thigh, or upper arm | Stomach, thigh, or upper arm |
| Time to max dose | ~21 weeks | ~17 weeks |
Who Should Not Use Mounjaro or Wegovy?
Not everyone is a candidate for these medications. Avoid or consult your doctor if you:
- Have severe heart, kidney, or liver problems
- Have a history of pancreatitis
- Experience severe gastrointestinal issues
- Already take another weight-loss medication
- Have diabetic retinopathy (eye damage caused by diabetes)
Final Thoughts: Mounjaro vs Wegovy – Which Is Right for You?
Both Mounjaro and Wegovy are highly effective weight loss medications, but they differ in strength, design, and results.
- Mounjaro: May deliver greater long-term weight loss due to its dual-hormone action.
- Wegovy: Specifically developed for obesity and may act slightly faster in the short term.
The best choice depends on your personal health, weight-loss goals, and doctor’s recommendation. Always consult with a healthcare professional before starting treatment.